Aim: To advance our understanding of nurses’ clinical decision-making concerning use of rapid tranqullisation in adult mental health inpatient settings. Methodology: An integrative review was conducted using the methodological framework described by Whittemore and Knafl (2005). Findings (preliminary): Altogether 151 meaning units were ed from 10 included studies; 11 categories were generated. Of these categories, five were related to the clinical decision-making process; six, to factors influencing and/or associated with nurses’ clinical decision-making. Significance for practice: Nurses play a crucial role in decisions regarding the use of rapid tranquillisation. Therefore, increased understanding of their clinical decision-making can inform interventions aimed at reducing use of rapid tranquillisation. Relevance for theme: This study synthesises knowledge about nurses use of rapid tranquillisation and thus how they use it in their daily nursing care and treatment.