Due to the COVID- 19 pandemic, isolation and distance learning are more likely to cause mood disorder in adolescents. Several literatures found listening music is the most commonly stress management strategy, and it can improve mood status and increase well-being. However, there is a lack of systematic empirical research in adolescents. According to the steps of evidence base research, it forms the basis for clinical implementation. To deliver music intervention to mood disorder adolescents, could in benefits in mood disorder and well-being. Participants can focus more on activities; it shows that music intervention may more suitable for mood disorder adolescents.